Sunday, August 20, 2017

Unprecedented Value and Meaning: Application of Artificial Intelligent Systems during Intense Data Driven Task of Preservation of Delicate Balance of Anabolic and Catabolic Processes During Cancer Care and Treatment as Related to Medical Research

My entry into the Astellas Oncology C3 Prize competition will focus upon application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs) to help guide patients through the healthcare system to reduce burden of decision making so that patients have more time to make better lifestyle choices that have potential to prolong life. In order to acheive a better prognosis it is vital that patients with cancer and other chronic wasting diseases are not unnecessarily burdened by healthcare decision making processes so that patients can focus upon making wise lifestyle choices that may prolong life while managing their personal health.


A person diagnosed with cancer is in a major battle for his or her life. Cancer is a chronic wasting disease whereby metabolism is shifted toward catabolism of healthy striated muscle tissue. Cancer begins with faulty DNA nucleotide instructions that produce cancerous cellular mutations during DNA - RNA replication. 

Lifestyle choices that an individual makes, including diet and exercise, is an intervention into unique metabolism of an individual. Lifestyle choices have a tremendous impact upon metabolism. When a person is suffering from a chronic wasting disease process like cancer often an individual makes poor lifestyle choices contributing toward shifting homeostasis of metabolism towards catabolism of healthy striated muscle tissue. 

If a sick person with cancer is put into a position where they must fight the healthcare system then this is detrimental to health of a cancer patient. An application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs) can potentially introduce efficiency of providing medical treatment. An increased efficiency in healthcare delivery may eliminate stress for cancer patients.

An increased food intake is a behavior strategy to compensate for lack of energy as a consequence of suffering from a chronic wasting disease. An increased food intake exposes an individual to a wider range of pathogenic carcinogens. 

Almost every chemical substance on earth in excess can become toxic including natural food products like simple sugar. Calorie restriction has been demonstrated by scientific studies to increase longevity.

Adipose tissue includes weak loose inefficient molecular bonds. Striated muscle tissue is more organized highly efficient tissue that is generally healthier than adipose tissue. 

An increase in adipose tissue can become a stress factor for surrounding healthy striated muscle tissue. When tissue is stressed muscle tissue becomes suspectiable to attack by cancerous cellular mutations. Also, chemotherapy may have a more detrimental impact upon adipose tissue comprised of weak loose inefficient molecular bonding.

A scientific research study published by The Open Obesity Journal entitled, A Diet and Exercise Intervention during Chemotherapy for Breast Cancer, substantiates that diet and exercise lifestyle choices can have major impact upon cancer prognosis.

In my original article posted below I identified endogenous steroid hormones as complex macromolecules that regulate metabolism. The delicate balance between catabolic and anabolic processes is a consequence of a complex interplay between endogenous steroid hormones and microbial activity within the human body.

A scientific article published by Endocrinolgy and Metabolism Clinics of North America entitled, The Microbes of the Intestine: An Introduction to Their Metabolic and Signaling Capabilities, identifies microbes as a hidden organ essential to health but simultaneously contribute to disease processes. Microbes as a hidden organ essential to health contribute to disease processes when conditions arise where microbe functioning is not synchronized with endogenous steroid hormone production and other biological systems.


The complex interplay between endogenous steroid hormones and microbial activity within the human body is a major reason why external lifestyle choices, including diet and exercise, has such a profound impact upon human metabolism. External lifestyle choices pertaining to healthy living alters complex interplay between endogenous steroid hormones and microbial activity that utimately regulate preservation of delicate balance between anabolic and catabolic processes comprising human metabolism

An understanding of metabolic processes dedicated to preservation of delicate balance between catabolic and anabolic systems within human body gives one a deeper appreciation for ability of an individual to take one more breath. One must choose to either embrace life by making healthy lifestyle choices or die. 

Bulwark of cumbersome organizational structure of an inefficient healthcare system creates impediments that prevent cancer patients from making healthy lifestyle choices. An application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs) may dramatically improve efficiency of healthcare delivery thereby providing more time for the cancer patient to engage in practices of healthy living.

A scientific research study conducted by Dr Susan A. Oliveria and I-Min Lee as published by Sports Medicine entitled, Is Exercise Beneficial in the Prevention of Prostate Cancer?, contains a revealing statement providing insight into the hypothesis that athletes with a certain level of endogenous testosterone may be biologically prone to cancer before certain athletes engage in doping. Dr Susan A. Oliveria and I-Min Lee write, 

"Studies have shown that men with prostate cancer have higher levels of endogenous testosterone than noncancerous men, and cancerous tissue has been reported to have higher levels of testosterone than healthy tissue. Athletes have been found to have lower levels of circulating testosterone than nonathletes, and men who exercise register a temporary reduction in testosterone levels post exercise."

 Hence, exercise is a major external factor in modulation of endogenous steroid production that may contribute to cancerous cell growth as well as spread of cancerous cellular mutations. 


Professional athletes engage in intense exercise work out regimens that can be viewed as chronic wasting disease process involving constant catabolic break down of weak tissue. Intense exercise work out regimens plus proper diet stimulate an increase in anabolic processes to replace weak tissue with stronger more efficient striated muscle fiber. 

An increase in anabolic and catabolic functions when one engages in an intense exercise regimen for long periods of time may ultimately contribute to an increase in errors that occur during RNA transcription that replicate DNA strands. An increase in errors during RNA transcription of DNA strands as a consequence of more anabolic and catabolic activity may create cancerous cellular mutations. 

If a professional athlete or weekend warrior chooses to engage in an intense exercise regime then it is important individuals are consistant in maintenance of an intense exercise regimen schedule. An increase in endogenous steroid production within interstitial tissue as a consequence of downtime from intense exercise regimens may contribute to spread of cancerous cellular mutations.

Consistancy and maintenance of intense exercise regimens is especially vital to professional athletes. As stated above, professional athletes engage in intense exercise work out regimens can be viewed as having a chronic wasting disease which is offset by anabolic building up of muscle mass

The use of anabolic steroids by professional athletes may help maintain consistency of an intense exercise regimen required for professional sports.   The use of anabolic steroids under guidance from a board certified sports medicine practitioner may contribute to maintenance of consistency of vigorous work out regimens endured by professional athletes. 

Maintenance of consistency of vigorous work out regimens by professional athletes by use of anabolic steroids under guidance from a board certified sports medicine practitioner may stimulate a healthy immunological response of decreasing high levels of naturally occurring endogenous steroids within interstitial tissue.  High levels of naturally occurring endogenous steroids within interstitial tissue can potentially lead to spread of cancerous cellular mutations that occur during RNA transcription replicationg DNA strands. Professional athletes may be more prone to errors occurring during RNA transcription of DNA strands because intense exercise regiments increase anabolic and catabolic processes comprising human metabolism 

Intense physical demands placed upon the professional athlete can be equated with a chronic wasting disease process that involves massive muscle catabolism, hence treatment with Anabolic Steroids and other performance enhancing drugs may be a legitimate medical practice by sports practitioners. 

According to CBS This Morning Dr. David Agus, professor of medicine and engineering at the University of Southern California published a study in Nature concerning how, “Good gut bacteria can help with controlling weight, inflammation”.






According to Dr. David Agus, there are 10X more microbial bacteria in the human body than there are human cells. Ironically, obese people have less microbial bacteria than thinner healthier more athletic people. Ironically, thinner healthier more athletic people have more microbial bacteria than obese people. The type of microbial bacteria that obese people have is a harmful type of bacteria that contributes to inflammation. Inflammation is major underlying contributing factor to multiple deadly diseases.

It is likely that obese people have less microbial bacteria than thinner healthier more athletic people because microbial bacteria do not thrive in adipose acidic amino acid environments as microbial bacterial may thrive within striated muscle tissue. Thinner more athletic people likely have more microbial bacteria than obese people because growth of microbial bacteria is fueled by endogenous steriod hormones. 

Endogenous steroid hormones that provide fuel for growth of good microbial bacteria is more readily available and abundant within striated muscle tissue as opposed to acidic amino acid environments of adipose tissue. Many scientific research studies demonstrate that after intense exercise spikes in endogenous steroid hormone profiles occur. A study published by the Journal of Applied Physiology entitled, Effect of training status and exercise mode on endogenous steroid hormones in men, provides a scientific analysis of spikes in hormone profiles after exercise.

Good microbial bacteria may play a role in a catabolic reaction of disassembling or disgesting complex macromolecules comprising endogenous steroid hormones. A catabolic process of microbial disassembling or disgesting complex macromolecules comprising endogenous steroid hormones may modulate anabolic and catabolic reactions that create errors in RNA transcription of DNA strands. When anabolic and catabolic reactions are reduced by microbial bacteria limiting amount of available interstitial endogenous steroid hormones then less errors occur during DNA replication causing cancerous cellular mutations.

According to Webmd.com, A diet rich in Omega 3 Fatty Acids can reduce harmful microbial bacteria that cause inflammation.

Inflammation of tissue may be a result of pathologies that arise from low concentrations of endogenous steroid hormones. Endogenous steroid hormones within interstitual cellular tissue play a vital major role in anabolic rebuilding of strong healthy muscle mass.

As stated in this article below,

The delicate balance between catabolic and anabolic processes comprising metabolism is regulated by the endocrine hormonal system. Speaking from a quantum perspective, endogenous steroid hormones naturally produced by human body are complex macromolecules that can both destroy cancerous cells or cause rapid spread of cancerous cells.

A discussion of exercise physiology within this article has direct implications pertaining to application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs) to improve healthcare delivery practices in such a way as to allow more time for cancer patients to make healthier lifestyle choices in managing personal health. Lifestyle choices, including diet and exercise, have a major impact upon physiological events. In order to secure a better prognosis an unnecessary burden of fighting an inefficient healthcare system should be removed from cancer patients by application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs).

An application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs) through artificial intelligent systems is a new innovation. Artificial intelligent systems powered by quantum molecular computation is not likely an in-house hospital or medical office operation. Today, quantum computers operate at low temperatures in special facilities.

An application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs) through artificial intelligent systems requires more study to pioneer procedures. Privacy of medical records is a major issue in application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs). Artificial intelligent quantum molecular computers allow advanced biometrics, such a finger print and retinal scans, to insure the right people have access to personal private medical records.

Also, more scientific study needs to be conducted pertaining to how lifestyle choices impact physiological events, which ultimately determine prognosis of a patient diagnosed with cancer. If I win the Astellas Oncology C3 Prize of $50,000 I plan to leverage power of the internet through a commercial grade website to fund a longitudinal study to determine how lifestyle choices impact physiological events, which ultimately determine prognosis of a patient diagnosed with cancer. A longitudinal study as I propose may involve application of Electronic Medical Records ( EMRs ) and Electronic Health Records ( EHRs).


Follow Up After Entry 
into Astellas Oncology C3 Prize
Competition


An article originally shared within the Google + Neuroscience community entitled, Endocrine cells in the brain influence the optimization of behavior, references a scientific research study published in Nature entitled, Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour

The results of the scientific study published in Nature supports my propositions that (1) The delicate balance between catabolic and anabolic processes comprising metabolism is regulated by the endocrine hormonal system, and (2) Endogenous steroid hormones, as complex macromolecules that regulate metabolism, can contribute to a cluster of multiple pathological diseases.

If the endocrine system, which includes cells within pituitary, prepares the human body to react to stressful events then it is only logical to assume that a chronic wasting disease such as cancer can potentially diminish ability of the human body to cope with stressful events. Hence, unnecessary stress created by an inefficient healthcare system can contribute to a poor prognosis for cancer patients.

A chronic wasting disease such as cancer will likely compromise the pituitary endocrine ability of the human body to cope with stress therefore cancer patients will be physically unable to engage in healthy behaviors conducive to longevity. Thus, the scientific study published in Nature entitled, Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour, makes it clear that it is imperative to remove as much as possible unnecessary stressful burden of an inefficient healthcare system upon cancer patients to insure a better prognosis.

A better prognosis for cancer patients is achieved by enabling ability of cancer patients to engage in behaviors of healthy living . An  application of Electronic Medical Records (EMRs) and Electronic Health Records (EHRs) can increase efficiency of healthcare system thereby removing unnecessary burden of stress upon cancer patients as a consequence of an inefficient healthcare system. 


My original Astellas Oncology C3 Prize entry is published on my commercial Facebook page, Reflection About Better Cancer Care. My commercial Facebook page Reflection About Better Cancer Care post includes my answers to three questions posed by Astellas: (1) Describe a problem in cancer care you are trying solve, (2) Describe your solution to the problem, and (3) How will you use the Astellas Oncology C3 Prize to bring your idea to life?

In reply to an IBM post entitled, The Power of You, I pointed out finding insights into decades of medical documents is what my entry into the #AstellasUS #C3Prize is all about. I helped #IBMWatson uncover a valuable insight to improve cancer care.

How Lifestyle Choices Influence Prognosis of Cancer by Altering Metabolism as Related to Greater Efficiency in Healthcare Delivery by applications of EMR and EHR
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https://www.facebook.com/Gatsby767/posts/1523387341058800?pnref=story




Original Freelance Article:
Metabolism As Related to Discovering a Cure for Cancer and other Pathological Disease Processes

By Mark W. Gaffney

https://introspectivemoments.wordpress.com/2017/02/19/first-blog-post/

I am always looking for a way to work together with my LinkedIn connections for mutual benefit in helping each other become more successful in accomplishing goals. I am open to any suggestions as to how I can better help my LinkedIn connections. I plan to attend a conference about how to make intelligent connections using social media hosted by Leadership Louisville.
More information about the Leadership Louisville conference featuring keynote speaker Erica Dhawan March 7, 2017 can be found on the website of Leadership Louisville.


The keynote speaker for the Leadership Louisville conference about making intelligent connections with social media is Erica Dhawan.


In the Forbes article, How Connectional Intelligence Can Make You Successful, the author Erica Dhawan poignantly shared,


“Connectional intelligence describes this skill that 21st century innovators have, and that we all need to develop, to maximize the potential of all of our connections and put them to significant use. It’s the ability to combine knowledge, ambition and human capital, forging connections on a global scale to create unprecedented value and meaning.”

In terms of forging connections on a global scale to create unprecedented value and meaning I wrote the following freelance article about application of artificial intelligent supercomputer platforms in medical research to discover cure to cancer and other diseases:

I would have a hard time believing that there are multiple ways to cure cancer, but cures are not released to public because medical treatment for cancer is a 200 billion dollar industry, as your post claims.






I can understand how it may be true. I have seen many mass media reports about amazing breakthroughs to cure cancer upon future horizon. However, those medical treatments have to be tested for many decades with animal and human test subjects before experimental medical treatments are considered safe.

Cancer is extremely difficult to cure because the disease involves an intricate delicate balance of catabolic and anabolic activity. Metabolism consist of two major forces, which are catabolism and anabolism. If a medical treatment tips the delicate balance of catabolic and anabolic processes slightly it may have fatal consequences.

The delicate balance between catabolic and anabolic processes comprising metabolism is regulated by the endocrine hormonal system. Speaking from a quantum perspective, endogenous steroid hormones naturally produced by human body are complex macromolecules that can both destroy cancerous cells or cause rapid spread of cancerous cells.

Endogenous steroid hormones as complex macromolecules that regulate metabolism can contribute to a cluster of multiple pathological diseases. Since multiple pathologies can arise as a consequence of endogenous hormones naturally produced in body any medical treatment designed to cure cancer must be careful to preserve the delicate balance of catabolic and anabolic processes.

An effort to preserve delicate balance of catabolic and anabolic processes regulated by complex endocrine hormonal macromolecules is a intense data driven task requiring an artificially intelligent supercomputer similar to IBM Watson.

#datadriven

It is for this reason I advocate advanced artificial intelligent supercomputer systems, like IBM Watson, be deployed in scientific research to find cures for cancer as rapidly as possible. Advance artificial intelligent supercomputer systems like IBM Watson can rapidly process changing metabolic data. Rapid change in metabolic data occurs due to a huge number of variables.

IBM Watson Health is dedicated to assisting in discovery of new cures for all pathological disease processes including cancer:

#WatsonHealth

Intense exercise regimens may be one of many variables that contributes to an imbalance of endogenous steroids naturally produced within the human body. An imbalance of endogenous steroids naturally produced within the human body can potentially fuel growth of cancerous cells.
My theoretical assertion that intense exercise regimens can potentially lead to an imbalance of endogenous steroids naturally produced within human body has highly important implications to professional athletics. Foods rich in Omega fatty acids may modulate growth and spread of pathological cancerous cells.

Foods rich in Omega fatty acids may modulate growth of pathological cancerous cells by providing fuel for microbes that feed upon excessive production of complex endogenous steroid macromolecules naturally produced in human body as consequence of intense exercise regimens. Also harmful microbes that play a major role in catabolic metabolism do not thrive in an environment where tissue is saturated with Omega fatty acids. When tissue is stressed by activity of harmful microbes than physiological consequences arise favorable to growth and spread of pathological cancerous cells.

My article provides valuable insight into problematic issues related to discovery of a cure for cancer. Since endogenous steroid hormones naturally produced by human body are complex macromolecules that can both destroy cancerous cells or cause rapid spread of cancerous cells, it is possible medical use of steroids by Lance Armstrong may have extended Lance Armstrong's life. 

An intense training regimen may have contributed to physiological events leading to a metabolic imbalance causative of Lance Armstrong's testicular cancer.


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Photograph courtesy of Alterfines @ Pixabay 
https://pixabay.com/en/users/Alterfines-1302079/

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